Assay Detail
Functional
CHEMBL4841976
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Agonist activity at human neuropeptide Y Y4 receptor expressed in HEK293T-ARRB1 cells assessed as stimulation of beta-arrestin 1 recruitment by multimode plate reader
42
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y<sub>4</sub> Receptor Ligands Results in Picomolar Binding Constants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 7.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856311 | — | — | 2 | 9.00 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | 2.0 | 2 | 8.66 |
| CHEMBL4857577 | — | — | 2 | 8.46 |
| CHEMBL4873376 | — | — | 2 | 8.44 |
| CHEMBL4848958 | — | — | 2 | 7.85 |
| CHEMBL4860290 | — | — | 2 | 7.31 |
| CHEMBL4863955 | — | — | 2 | 7.07 |
| CHEMBL4870168 | — | — | 2 | 6.94 |
| CHEMBL4874850 | — | — | 2 | 6.91 |
| CHEMBL4852799 | — | — | 2 | 6.90 |
| CHEMBL4865048 | — | — | 2 | 6.80 |
| CHEMBL4633593 | — | — | 2 | 6.79 |
| CHEMBL4866086 | — | — | 2 | 6.75 |
| CHEMBL4862140 | — | — | 2 | 6.57 |
| CHEMBL4858915 | — | — | 2 | 6.54 |
| CHEMBL4874445 | — | — | 2 | 6.28 |
| CHEMBL4877802 | — | — | 2 | 6.00 |
| CHEMBL4866955 | — | — | 2 | - |
| CHEMBL4852354 | — | — | 2 | - |
| CHEMBL4868787 | — | — | 2 | - |
| CHEMBL4861544 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856311 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4856311 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | EC50 | = | 2.188 | nM | 8.66 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4857577 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4857577 | — | EC50 | = | 3.548 | nM | 8.45 |
| CHEMBL4873376 | — | EC50 | = | 3.631 | nM | 8.44 |
| CHEMBL4873376 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4848958 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4848958 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL4860290 | — | EC50 | = | 48.98 | nM | 7.31 |
| CHEMBL4860290 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4863955 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL4870168 | — | EC50 | = | 114.82 | nM | 6.94 |
| CHEMBL4870168 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4874850 | — | EC50 | = | 123.03 | nM | 6.91 |
| CHEMBL4852799 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4852799 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4865048 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4865048 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4633593 | — | EC50 | = | 162.18 | nM | 6.79 |
| CHEMBL4633593 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4866086 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4866086 | — | EC50 | = | 181.97 | nM | 6.74 |
| CHEMBL4862140 | — | EC50 | = | 269.15 | nM | 6.57 |
| CHEMBL4862140 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4858915 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4858915 | — | EC50 | = | 288.4 | nM | 6.54 |
| CHEMBL4874445 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL4874445 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4877802 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4877802 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4861544 | — | EC50 | - | — | - | |
| CHEMBL4868787 | — | EC50 | - | — | - | |
| CHEMBL4874850 | — | EC50 | - | — | - | |
| CHEMBL4852354 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4866955 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4863955 | — | EC50 | - | — | - | |
| CHEMBL4852354 | — | EC50 | - | — | - | |
| CHEMBL4861544 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4866955 | — | EC50 | - | — | - | |
| CHEMBL4868787 | — | EC50 | > | 10000.0 | nM | - |