Assay Detail
Functional
CHEMBL4841978
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Agonist activity at human neuropeptide Y Y4 receptor expressed in HEK293T-ARRB2 cells assessed as stimulation of beta-arrestin 2 recruitment by multimode plate reader
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y<sub>4</sub> Receptor Ligands Results in Picomolar Binding Constants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.26 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873376 | — | — | 1 | 8.80 |
| CHEMBL4856311 | — | — | 1 | 8.78 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | 2.0 | 1 | 8.37 |
| CHEMBL4857577 | — | — | 1 | 8.27 |
| CHEMBL4848958 | — | — | 1 | 7.89 |
| CHEMBL4874850 | — | — | 1 | 7.05 |
| CHEMBL4866086 | — | — | 1 | 7.03 |
| CHEMBL4852799 | — | — | 1 | 7.02 |
| CHEMBL4633593 | — | — | 1 | 6.95 |
| CHEMBL4860290 | — | — | 1 | 6.89 |
| CHEMBL4865048 | — | — | 1 | 6.85 |
| CHEMBL4863955 | — | — | 1 | 6.84 |
| CHEMBL4870168 | — | — | 1 | 6.79 |
| CHEMBL4858915 | — | — | 1 | 6.75 |
| CHEMBL4862140 | — | — | 1 | 6.53 |
| CHEMBL4874445 | — | — | 1 | 6.45 |
| CHEMBL4877802 | — | — | 1 | 6.12 |
| CHEMBL4866955 | — | — | 1 | - |
| CHEMBL4852354 | — | — | 1 | - |
| CHEMBL4868787 | — | — | 1 | - |
| CHEMBL4861544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873376 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4856311 | — | EC50 | = | 1.66 | nM | 8.78 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | EC50 | = | 4.266 | nM | 8.37 |
| CHEMBL4857577 | — | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL4848958 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL4874850 | — | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL4866086 | — | EC50 | = | 93.33 | nM | 7.03 |
| CHEMBL4852799 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL4633593 | — | EC50 | = | 112.2 | nM | 6.95 |
| CHEMBL4860290 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL4865048 | — | EC50 | = | 141.25 | nM | 6.85 |
| CHEMBL4863955 | — | EC50 | = | 144.54 | nM | 6.84 |
| CHEMBL4870168 | — | EC50 | = | 162.18 | nM | 6.79 |
| CHEMBL4858915 | — | EC50 | = | 177.83 | nM | 6.75 |
| CHEMBL4862140 | — | EC50 | = | 295.12 | nM | 6.53 |
| CHEMBL4874445 | — | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL4877802 | — | EC50 | = | 758.58 | nM | 6.12 |
| CHEMBL4866955 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4852354 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4868787 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4861544 | — | EC50 | > | 10000.0 | nM | - |