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Assay Detail

CHEMBL5033659

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Trypanocidal activity against Trypanosoma cruzi MHOM/MX/1994/Ninoa assessed as inhibition of parasite growth measured after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

In vitro, ex vivo and in vivo short-term screening of DHEA nitrate derivatives activity over Trypanosoma cruzi Ninoa and TH strains from Oaxaca State, México.
Domínguez-Díaz LR, Eugenia Ochoa M, Soto-Castro D, Farfán N, Morales-Chamorro M, Yépez-Mulia L, Pérez-Campos E, Santillan R, Moreno-Rodríguez A.
Bioorg Med Chem (2021) 48 : 116417 -116417
PubMed 34571489 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.89 5.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5077084 1 5.67
CHEMBL440283 ANDROSTENEDIOL -1.0 1 5.65
CHEMBL5071567 1 5.55
CHEMBL290960 NIFURTIMOX 4.0 1 5.15
CHEMBL110 BENZNIDAZOLE 4.0 1 4.52
CHEMBL5075288 1 4.48
CHEMBL5093839 1 4.44
CHEMBL5079196 1 4.32
CHEMBL90593 PRASTERONE 4.0 1 4.21
CHEMBL5083602 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5077084 IC50 = 2120.0 nM 5.67
CHEMBL440283 ANDROSTENEDIOL IC50 = 2230.0 nM 5.65
CHEMBL5071567 IC50 = 2800.0 nM 5.55
CHEMBL290960 NIFURTIMOX IC50 = 7090.0 nM 5.15
CHEMBL110 BENZNIDAZOLE IC50 = 30270.0 nM 4.52
CHEMBL5075288 IC50 = 33200.0 nM 4.48
CHEMBL5093839 IC50 = 36170.0 nM 4.44
CHEMBL5079196 IC50 = 48300.0 nM 4.32
CHEMBL90593 PRASTERONE IC50 = 62000.0 nM 4.21
CHEMBL5083602 IC50 = 346900.0 nM -