Assay Detail
Functional
CHEMBL5104545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma cruzi Y trypomastigotes infected in Swiss Webster mouse assessed as reduction in viable parasite in blood incubated for 24 hrs by Neubauer counting chamber based light microscopic analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.34 | 4.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183153 | — | — | 1 | 4.42 |
| CHEMBL3609557 | — | — | 1 | 4.26 |
| CHEMBL3609552 | — | — | 1 | - |
| CHEMBL3609558 | — | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183153 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL3609557 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL3609552 | — | IC50 | = | 102900.0 | nM | - |
| CHEMBL3609558 | — | IC50 | = | 109200.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 103600.0 | nM | - |