Assay Detail
Functional
CHEMBL5104547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma cruzi Y amastigotes infected in monkey LLC-MK2 cells assessed as parasite growth inhibition incubated for 5 days by Neubauer hemocytometer based fluorescence spectrophotometer method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | LLC-MK2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.57 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.70 |
| CHEMBL4585853 | — | — | 1 | 4.68 |
| CHEMBL4462900 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 19930.0 | nM | 4.70 |
| CHEMBL4585853 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4462900 | — | IC50 | = | 46800.0 | nM | 4.33 |