Assay Detail
Functional
CHEMBL5104549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma cruzi Y trypomastigotes infected in albino mouse assessed as reduction in viable parasite in blood by Neubauer counting chamber method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.18 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196085 | — | — | 1 | 4.28 |
| CHEMBL3609557 | — | — | 1 | 4.26 |
| CHEMBL3952951 | — | — | 1 | 4.26 |
| CHEMBL4585853 | — | — | 1 | 4.06 |
| CHEMBL3908949 | — | — | 1 | 4.05 |
| CHEMBL3609552 | — | — | 1 | - |
| CHEMBL3609558 | — | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
| CHEMBL3621996 | — | — | 1 | - |
| CHEMBL3945406 | — | — | 1 | - |
| CHEMBL5205333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196085 | — | IC50 | = | 52900.0 | nM | 4.28 |
| CHEMBL3609557 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL3952951 | — | IC50 | = | 55300.0 | nM | 4.26 |
| CHEMBL4585853 | — | IC50 | = | 86700.0 | nM | 4.06 |
| CHEMBL3908949 | — | IC50 | = | 89500.0 | nM | 4.05 |
| CHEMBL3609552 | — | IC50 | = | 102900.0 | nM | - |
| CHEMBL3609558 | — | IC50 | = | 109200.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 103600.0 | nM | - |
| CHEMBL3621996 | — | IC50 | = | 230200.0 | nM | - |
| CHEMBL3945406 | — | IC50 | = | 213500.0 | nM | - |
| CHEMBL5205333 | — | IC50 | = | 208900.0 | nM | - |