Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5115680

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against intracellularTrypanosoma cruzi amastigote
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368) ↗
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.
McGonagle K, Tarver GJ, Cantizani J, Cotillo I, Dodd PG, Ferguson L, Gilbert IH, Marco M, Miles T, Naylor C, Osuna-Cabello M, Paterson C, Read KD, Pinto EG, Riley J, Scullion P, Shishikura Y, Simeons F, Stojanovski L, Svensen N, Thomas J, Wyatt PG, Manzano P, De Rycker M, Thomas MG.
Eur J Med Chem (2022) 238 : 114421 -114421
PubMed 35594652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 47 5.43 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5171327 — — 1 6.80
CHEMBL5187467 — — 1 6.80
CHEMBL5181614 — — 1 6.70
CHEMBL3546548 — — 1 6.40
CHEMBL5195708 — — 1 6.30
CHEMBL5186876 — — 1 6.20
CHEMBL5186388 — — 1 6.00
CHEMBL5187359 — — 1 6.00
CHEMBL5179868 — — 1 5.90
CHEMBL5204107 — — 1 5.80
CHEMBL5200127 — — 1 5.70
CHEMBL5205066 — — 1 5.50
CHEMBL5206675 — — 1 5.50
CHEMBL5185578 — — 1 5.50
CHEMBL5185400 — — 1 5.40
CHEMBL5195813 — — 1 5.40
CHEMBL5205296 — — 1 5.30
CHEMBL5174062 — — 1 5.30
CHEMBL5208894 — — 1 5.20
CHEMBL5198680 — — 1 5.20
CHEMBL5198955 — — 1 5.20
CHEMBL5195923 — — 1 5.20
CHEMBL5205362 — — 1 5.10
CHEMBL5197401 — — 1 5.10
CHEMBL5191547 — — 1 5.00
CHEMBL5173853 — — 1 5.00
CHEMBL5173156 — — 1 4.90
CHEMBL5196386 — — 1 4.90
CHEMBL5205290 — — 1 4.80
CHEMBL5177328 — — 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5171327 — EC50 = 158.49 nM 6.80
CHEMBL5187467 — EC50 = 158.49 nM 6.80
CHEMBL5181614 — EC50 = 199.53 nM 6.70
CHEMBL3546548 — EC50 = 398.11 nM 6.40
CHEMBL5195708 — EC50 = 501.19 nM 6.30
CHEMBL5186876 — EC50 = 630.96 nM 6.20
CHEMBL5186388 — EC50 = 1000.0 nM 6.00
CHEMBL5187359 — EC50 = 1000.0 nM 6.00
CHEMBL5179868 — EC50 = 1258.93 nM 5.90
CHEMBL5204107 — EC50 = 1584.89 nM 5.80
CHEMBL5200127 — EC50 = 1995.26 nM 5.70
CHEMBL5206675 — EC50 = 3162.28 nM 5.50
CHEMBL5185578 — EC50 = 3162.28 nM 5.50
CHEMBL5205066 — EC50 = 3162.28 nM 5.50
CHEMBL5195813 — EC50 = 3981.07 nM 5.40
CHEMBL5185400 — EC50 = 3981.07 nM 5.40
CHEMBL5205296 — EC50 = 5011.87 nM 5.30
CHEMBL5174062 — EC50 = 5011.87 nM 5.30
CHEMBL5208894 — EC50 = 6309.57 nM 5.20
CHEMBL5198680 — EC50 = 6309.57 nM 5.20
CHEMBL5198955 — EC50 = 6309.57 nM 5.20
CHEMBL5195923 — EC50 = 6309.57 nM 5.20
CHEMBL5197401 — EC50 = 7943.28 nM 5.10
CHEMBL5205362 — EC50 = 7943.28 nM 5.10
CHEMBL5191547 — EC50 = 10000.0 nM 5.00
CHEMBL5173853 — EC50 = 10000.0 nM 5.00
CHEMBL5173156 — EC50 = 12589.25 nM 4.90
CHEMBL5196386 — EC50 = 12589.25 nM 4.90
CHEMBL5205290 — EC50 = 15848.93 nM 4.80
CHEMBL5177328 — EC50 = 15848.93 nM 4.80
CHEMBL5198768 — EC50 = 15848.93 nM 4.80
CHEMBL5171508 — EC50 = 15848.93 nM 4.80
CHEMBL5194318 — EC50 = 19952.62 nM 4.70
CHEMBL5195384 — EC50 = 25118.86 nM 4.60
CHEMBL5178331 — EC50 = 50118.72 nM 4.30
CHEMBL5196051 — EC50 > 50118.72 nM -
CHEMBL5184676 — EC50 > 50118.72 nM -
CHEMBL5174453 — EC50 > 50118.72 nM -
CHEMBL5204051 — EC50 > 50118.72 nM -
CHEMBL5193764 — EC50 > 50118.72 nM -
CHEMBL5185181 — EC50 > 50118.72 nM -
CHEMBL5200858 — EC50 > 50118.72 nM -
CHEMBL5194351 — EC50 > 50118.72 nM -
CHEMBL5190564 — EC50 > 50118.72 nM -
CHEMBL5195080 — EC50 > 50118.72 nM -
CHEMBL5209474 — EC50 > 50118.72 nM -
CHEMBL5178648 — EC50 > 50118.72 nM -