Assay Detail
ADMET
CHEMBL5117644
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Inhibition of CYP2C9 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.76 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 6.46 |
| CHEMBL782 | TOLBUTAMIDE | 4.0 | 1 | 6.39 |
| CHEMBL5194948 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL782 | TOLBUTAMIDE | IC50 | = | 404.0 | nM | 6.39 |
| CHEMBL5194948 | — | IC50 | = | 38300.0 | nM | 4.42 |