Assay Detail
Functional
CHEMBL5135073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against intracellular Trypanosoma cruzi Tulahuen amastigotes expressing CL2 beta-galactosidase in human MRC5 cells assessed as parasite growth inhibition using chlorophenol red beta-D-galactopyranoside as substrate treated for 7 days by spectrophotometry
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N<sup>6</sup>-modification of 7-Deazapurine nucleoside analogues as Anti-Trypanosoma cruzi and anti-Leishmania agents: Structure-activity relationship exploration and In vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 5.31 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | — | 1 | 6.47 |
| CHEMBL3126898 | — | — | 1 | 6.35 |
| CHEMBL5174803 | — | — | 1 | 5.87 |
| CHEMBL3126906 | — | — | 1 | 5.78 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.64 |
| CHEMBL4436060 | — | — | 1 | 5.64 |
| CHEMBL5200044 | — | — | 1 | 5.64 |
| CHEMBL5205233 | — | — | 1 | 5.59 |
| CHEMBL5199723 | — | — | 1 | 5.38 |
| CHEMBL5195584 | — | — | 1 | 5.29 |
| CHEMBL5196805 | — | — | 1 | 5.18 |
| CHEMBL5182317 | — | — | 1 | 5.13 |
| CHEMBL5207202 | — | — | 1 | 5.11 |
| CHEMBL262874 | — | — | 1 | 5.11 |
| CHEMBL5174504 | — | — | 1 | 5.11 |
| CHEMBL98424 | — | — | 1 | 5.10 |
| CHEMBL5170491 | — | — | 1 | 4.85 |
| CHEMBL5203151 | — | — | 1 | 4.84 |
| CHEMBL5187821 | — | — | 1 | 4.49 |
| CHEMBL5178932 | — | — | 1 | 4.48 |
| CHEMBL4782563 | — | — | 1 | 4.47 |
| CHEMBL5189880 | — | — | 1 | - |
| CHEMBL2023963 | — | — | 1 | - |
| CHEMBL5207667 | — | — | 1 | - |
| CHEMBL5191825 | — | — | 1 | - |
| CHEMBL5194808 | — | — | 1 | - |
| CHEMBL5184615 | — | — | 1 | - |
| CHEMBL5180850 | — | — | 1 | - |
| CHEMBL5169613 | — | — | 1 | - |
| CHEMBL5209135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3126898 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5174803 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3126906 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4436060 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5200044 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL5205233 | — | EC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5199723 | — | EC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL5195584 | — | EC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL5196805 | — | EC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL5182317 | — | EC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL5207202 | — | EC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL262874 | — | EC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL5174504 | — | EC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL98424 | — | EC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL5170491 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5203151 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL5187821 | — | EC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL5178932 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4782563 | — | EC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL5189880 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL2023963 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5207667 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5191825 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5194808 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5184615 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5180850 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5169613 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5209135 | — | EC50 | > | 64000.0 | nM | - |