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Assay Detail

CHEMBL5159489

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against amastigotes form of Trypanosoma cruzi CA-I/72 infected in mouse C2C12 cells assessed as parasite infection level by DAPI staining based microscopic analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against <i>Trypanosoma cruzi</i>.
Barbosa Da Silva E, Sharma V, Hernandez-Alvarez L, Tang AH, Stoye A, O'Donoghue AJ, Gerwick WH, Payne RJ, McKerrow JH, Podust LM.
J Med Chem (2022) 65 : 4255 -4269
PubMed 35188371 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 7.11 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4596414 1 7.92
CHEMBL5171874 1 7.89
CHEMBL4596647 1 7.75
CHEMBL4597308 1 7.75
CHEMBL5184737 1 7.72
CHEMBL5176188 1 7.72
CHEMBL4596992 1 7.52
CHEMBL4598338 1 7.40
CHEMBL4595664 1 7.25
CHEMBL4596941 1 7.24
CHEMBL5204190 1 7.23
CHEMBL5191563 1 7.11
CHEMBL3558756 1 7.07
CHEMBL4595559 1 6.71
CHEMBL5183942 1 6.65
CHEMBL5199542 1 6.58
CHEMBL5179302 1 6.38
CHEMBL5175270 1 6.37
CHEMBL5202965 1 6.28
CHEMBL110 BENZNIDAZOLE 4.0 1 5.72
CHEMBL4595223 1 -
CHEMBL4595806 1 -
CHEMBL4594870 1 -
CHEMBL4594757 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4596414 EC50 = 12.0 nM 7.92
CHEMBL5171874 EC50 = 13.0 nM 7.89
CHEMBL4596647 EC50 = 18.0 nM 7.75
CHEMBL4597308 EC50 = 18.0 nM 7.75
CHEMBL5184737 EC50 = 19.0 nM 7.72
CHEMBL5176188 EC50 = 19.0 nM 7.72
CHEMBL4596992 EC50 = 30.0 nM 7.52
CHEMBL4598338 EC50 = 40.0 nM 7.40
CHEMBL4595664 EC50 = 56.0 nM 7.25
CHEMBL4596941 EC50 = 58.0 nM 7.24
CHEMBL5204190 EC50 = 59.0 nM 7.23
CHEMBL5191563 EC50 = 78.0 nM 7.11
CHEMBL3558756 EC50 = 85.0 nM 7.07
CHEMBL4595559 EC50 = 196.0 nM 6.71
CHEMBL5183942 EC50 = 222.0 nM 6.65
CHEMBL5199542 EC50 = 261.0 nM 6.58
CHEMBL5179302 EC50 = 420.0 nM 6.38
CHEMBL5175270 EC50 = 423.0 nM 6.37
CHEMBL5202965 EC50 = 521.0 nM 6.28
CHEMBL110 BENZNIDAZOLE EC50 = 1910.0 nM 5.72
CHEMBL4595223 EC50 > 600.0 nM -
CHEMBL4595806 EC50 > 600.0 nM -
CHEMBL4594870 EC50 > 600.0 nM -
CHEMBL4594757 EC50 > 600.0 nM -