Assay Detail
Functional
CHEMBL5159760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against influenza A virus H5N1 infected in dog MDCK cells assessed as inhibition of viral cytopathic effect incubated for 48 hrs by CCK-8 assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 48 | 6.30 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201341 | — | — | 1 | 8.03 |
| CHEMBL5194584 | — | — | 1 | 7.75 |
| CHEMBL5178040 | — | — | 1 | 7.64 |
| CHEMBL3779938 | — | — | 1 | 7.51 |
| CHEMBL3780361 | — | — | 1 | 7.47 |
| CHEMBL5175335 | — | — | 1 | 7.47 |
| CHEMBL3781624 | — | — | 1 | 7.43 |
| CHEMBL3781846 | — | — | 1 | 7.34 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.12 |
| CHEMBL3781230 | — | — | 1 | 7.11 |
| CHEMBL3781710 | — | — | 1 | 7.11 |
| CHEMBL5178591 | — | — | 1 | 7.08 |
| CHEMBL3781072 | — | — | 1 | 7.00 |
| CHEMBL3781483 | — | — | 1 | 6.72 |
| CHEMBL3780944 | — | — | 1 | 6.66 |
| CHEMBL5204752 | — | — | 1 | 6.64 |
| CHEMBL5184516 | — | — | 1 | 6.64 |
| CHEMBL5206488 | — | — | 1 | 6.48 |
| CHEMBL5208502 | — | — | 1 | 6.34 |
| CHEMBL5208343 | — | — | 1 | 5.92 |
| CHEMBL3781695 | — | — | 1 | 5.64 |
| CHEMBL3780114 | — | — | 1 | 5.39 |
| CHEMBL5187000 | — | — | 1 | 5.38 |
| CHEMBL5180125 | — | — | 1 | 5.36 |
| CHEMBL5193559 | — | — | 1 | 5.11 |
| CHEMBL5182627 | — | — | 1 | 4.89 |
| CHEMBL5205594 | — | — | 1 | 4.66 |
| CHEMBL5169657 | — | — | 1 | 4.62 |
| CHEMBL3780582 | — | — | 1 | 4.51 |
| CHEMBL3781814 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201341 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5194584 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5178040 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3779938 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3780361 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5175335 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3781624 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3781846 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3781230 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3781710 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5178591 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3781072 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3781483 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3780944 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5204752 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5184516 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5206488 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5208502 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5208343 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3781695 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3780114 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5187000 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5180125 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5193559 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5182627 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5205594 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5169657 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3780582 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3781814 | — | EC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL5193542 | — | EC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL3780079 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3781911 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1439655 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1433287 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5176247 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5208684 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5209145 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5201682 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3780638 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5207652 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5186056 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5193539 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5190537 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5209525 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5198807 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5195226 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5170639 | — | EC50 | > | 100000.0 | nM | - |