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Assay Detail

CHEMBL5163496

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-1 adrenergic receptor (CHEMBL213)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a Highly Selective β<sub>2</sub>-Adrenoceptor Agonist with a 2-Amino-2-phenylethanol Scaffold as an Oral Antiasthmatic Agent.
Xing G, Li D, Woo AY, Zhi Z, Ji L, Xing R, Lv H, He B, An H, Zhao H, Lin B, Pan L, Cheng M.
J Med Chem (2022) 65 : 5514 -5527
PubMed 35360904 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 8.81 8.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL714 ALBUTEROL 4.0 1 8.81
CHEMBL5203966 1 -
CHEMBL5172759 1 -
CHEMBL5191729 1 -
CHEMBL5186069 1 -
CHEMBL5186002 1 -
CHEMBL5176025 1 -
CHEMBL5183062 1 -
CHEMBL5194651 1 -
CHEMBL5190852 1 -
CHEMBL5187056 1 -
CHEMBL5192245 1 -
CHEMBL5178340 1 -
CHEMBL5195910 1 -
CHEMBL5200165 1 -
CHEMBL5201243 1 -
CHEMBL5200823 1 -
CHEMBL5208931 1 -
CHEMBL5196966 1 -
CHEMBL434 ISOPROTERENOL 4.0 1 -
CHEMBL5190961 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL714 ALBUTEROL EC50 = 1.53 nM 8.81
CHEMBL5203966 EC50 > 100000.0 nM -
CHEMBL5172759 EC50 > 100000.0 nM -
CHEMBL5191729 EC50 > 100000.0 nM -
CHEMBL5186069 EC50 > 100000.0 nM -
CHEMBL5186002 EC50 > 100000.0 nM -
CHEMBL5176025 EC50 > 100000.0 nM -
CHEMBL5183062 EC50 > 100000.0 nM -
CHEMBL5194651 EC50 > 100000.0 nM -
CHEMBL5190852 EC50 > 100000.0 nM -
CHEMBL5187056 EC50 > 100000.0 nM -
CHEMBL5192245 EC50 > 100000.0 nM -
CHEMBL5178340 EC50 > 100000.0 nM -
CHEMBL5195910 EC50 > 100000.0 nM -
CHEMBL5200165 EC50 > 100000.0 nM -
CHEMBL5201243 EC50 > 100000.0 nM -
CHEMBL5200823 EC50 > 100000.0 nM -
CHEMBL5208931 EC50 > 100000.0 nM -
CHEMBL5196966 EC50 > 100000.0 nM -
CHEMBL434 ISOPROTERENOL EC50 = 1000.0 nM -
CHEMBL5190961 EC50 > 100000.0 nM -