Assay Detail
Binding
CHEMBL5217749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2-<i>b</i>]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.70 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220871 | — | — | 1 | 8.80 |
| CHEMBL5218602 | — | — | 1 | 8.72 |
| CHEMBL5218768 | — | — | 1 | 8.62 |
| CHEMBL5220411 | — | — | 1 | 8.52 |
| CHEMBL5219987 | — | — | 1 | 8.19 |
| CHEMBL5218465 | — | — | 1 | 8.00 |
| CHEMBL5220465 | — | — | 1 | 7.96 |
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 7.92 |
| CHEMBL5220013 | — | — | 1 | 7.92 |
| CHEMBL5219759 | — | — | 1 | 7.89 |
| CHEMBL5218776 | — | — | 1 | 7.85 |
| CHEMBL5219980 | — | — | 1 | 7.82 |
| CHEMBL5220583 | — | — | 1 | 7.80 |
| CHEMBL5220381 | — | — | 1 | 7.80 |
| CHEMBL5219850 | — | — | 1 | 7.75 |
| CHEMBL5220764 | — | — | 1 | 7.75 |
| CHEMBL5220620 | — | — | 1 | 7.75 |
| CHEMBL5218566 | — | — | 1 | 7.72 |
| CHEMBL5220860 | — | — | 1 | 7.68 |
| CHEMBL5219709 | — | — | 1 | 7.57 |
| CHEMBL5218951 | — | — | 1 | 7.57 |
| CHEMBL5219434 | — | — | 1 | 7.57 |
| CHEMBL5219757 | — | — | 1 | 7.55 |
| CHEMBL5220291 | — | — | 1 | 7.46 |
| CHEMBL5219465 | — | — | 1 | 7.41 |
| CHEMBL5219501 | — | — | 1 | 7.40 |
| CHEMBL5221064 | — | — | 1 | 7.40 |
| CHEMBL5220403 | — | — | 1 | 7.38 |
| CHEMBL5218808 | — | — | 1 | 7.35 |
| CHEMBL5218837 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220871 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5218602 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5218768 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5220411 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5219987 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5218465 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5220465 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3908979 | FGF401 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5220013 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5219759 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5218776 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5219980 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5220583 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5220381 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5220764 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5220620 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5219850 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5218566 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5220860 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5219709 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5218951 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5219434 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5219757 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5220291 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5219465 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5219501 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5221064 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5220403 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5218808 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5218837 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL5219150 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL5219257 | — | IC50 | = | 578.0 | nM | 6.24 |