Compound Detail
CHEMBL5218602
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Basic Information
| ChEMBL ID | CHEMBL5218602 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VKDXHKJJXMNLPX-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
446.5
MW (Da)
1.56
ALogP
9
HBA
2
HBD
119.2
PSA (Ų)
0.53
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
| BaF3 CHEMBL614524 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| NCI-H1299 CHEMBL612255 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
| Hep 3B2 CHEMBL4296437 | IC50 | 4.82 | 4.82 | 15200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 1.9 | nM | 8.72 | Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide ... | 36278929 |
| BaF3 | IC50 | = | 16.0 | nM | 7.8 | Antiproliferative activity against mouse BaF3 cells transfected with human FGFR4... | 36278929 |
| NCI-H1299 | IC50 | = | 10000.0 | nM | 5.0 | Antiproliferative activity against human NCI-H1299 cells assessed as inhibition ... | 36278929 |
| Hep 3B2 | IC50 | = | 15200.0 | nM | 4.82 | Antiproliferative activity against human Hep3B cells assessed as inhibition of c... | 36278929 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 4 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 1 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 2 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 3 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | BaF3 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Hep 3B2 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | NCI-H1299 | 1 |
Data from ChEMBL 36 via Core Engine