Assay Detail
Functional
CHEMBL5217754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth measured after 5 days by SRB analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2-<i>b</i>]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.98 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 8.00 |
| CHEMBL5220381 | — | — | 1 | 7.43 |
| CHEMBL5220764 | — | — | 1 | 7.14 |
| CHEMBL5218951 | — | — | 1 | 6.96 |
| CHEMBL5219434 | — | — | 1 | 6.95 |
| CHEMBL5220583 | — | — | 1 | 6.86 |
| CHEMBL5219987 | — | — | 1 | 6.58 |
| CHEMBL5219709 | — | — | 1 | 6.54 |
| CHEMBL5220620 | — | — | 1 | 6.52 |
| CHEMBL5218808 | — | — | 1 | 6.41 |
| CHEMBL5219465 | — | — | 1 | 6.29 |
| CHEMBL5218776 | — | — | 1 | 6.25 |
| CHEMBL5220403 | — | — | 1 | 6.24 |
| CHEMBL5219757 | — | — | 1 | 6.24 |
| CHEMBL5219759 | — | — | 1 | 6.10 |
| CHEMBL5221064 | — | — | 1 | 6.05 |
| CHEMBL5218566 | — | — | 1 | 5.91 |
| CHEMBL5219850 | — | — | 1 | 5.88 |
| CHEMBL5220465 | — | — | 1 | 5.73 |
| CHEMBL5219980 | — | — | 1 | 5.46 |
| CHEMBL5220860 | — | — | 1 | 5.08 |
| CHEMBL5218768 | — | — | 1 | 4.92 |
| CHEMBL5218465 | — | — | 1 | 4.84 |
| CHEMBL5218602 | — | — | 1 | 4.82 |
| CHEMBL5218837 | — | — | 1 | 4.77 |
| CHEMBL5220871 | — | — | 1 | 4.57 |
| CHEMBL5219257 | — | — | 1 | 4.46 |
| CHEMBL5219501 | — | — | 1 | 4.45 |
| CHEMBL5219150 | — | — | 1 | - |
| CHEMBL5220411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3908979 | FGF401 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5220381 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5220764 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5218951 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5219434 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5220583 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL5219987 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL5219709 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL5220620 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL5218808 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL5219465 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL5218776 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL5220403 | — | IC50 | = | 578.0 | nM | 6.24 |
| CHEMBL5219757 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL5219759 | — | IC50 | = | 796.0 | nM | 6.10 |
| CHEMBL5221064 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL5218566 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5219850 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL5220465 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL5219980 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL5220860 | — | IC50 | = | 8280.0 | nM | 5.08 |
| CHEMBL5218768 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5218465 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL5218602 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL5218837 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL5220871 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL5219257 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5219501 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL5219150 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5220411 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL5220013 | — | IC50 | = | 630000.0 | nM | - |