Compound Detail
CHEMBL5218808
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CC(Oc1cc(NC(=O)c2cn(CCN3CCOCC3)c3cc(Br)c(C=O)nc23)ncc1C#N)c1c(Cl)cccc1Cl
Basic Information
| ChEMBL ID | CHEMBL5218808 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QNEOFQSEYLTNNA-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
672.4
MW (Da)
5.91
ALogP
9
HBA
1
HBD
122.4
PSA (Ų)
0.22
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| BaF3 CHEMBL614524 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
| Hep 3B2 CHEMBL4296437 | IC50 | 6.41 | 6.41 | 393.0 | 1 |
| NCI-H1299 CHEMBL612255 | IC50 | 5.68 | 5.68 | 2090.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| BaF3 | IC50 | = | 15.0 | nM | 7.82 | Antiproliferative activity against mouse BaF3 cells transfected with human FGFR4... | 36278929 |
| Fibroblast growth factor receptor 4 | IC50 | = | 45.0 | nM | 7.35 | Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide ... | 36278929 |
| Hep 3B2 | IC50 | = | 393.0 | nM | 6.41 | Antiproliferative activity against human Hep3B cells assessed as inhibition of c... | 36278929 |
| NCI-H1299 | IC50 | = | 2090.0 | nM | 5.68 | Antiproliferative activity against human NCI-H1299 cells assessed as inhibition ... | 36278929 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 4 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 1 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 2 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Fibroblast growth factor receptor 3 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | BaF3 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | Hep 3B2 | 1 |
| 36278929 | 10.1021/acs.jmedchem.2c01319 | NCI-H1299 | 1 |
Data from ChEMBL 36 via Core Engine