Assay Detail
Binding
CHEMBL5229154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measured after 2 hrs by fluorescence based analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase FTO (CHEMBL2331065) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.79 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572939 | — | — | 1 | 7.22 |
| CHEMBL465179 | — | — | 1 | 6.47 |
| CHEMBL5275957 | — | — | 1 | 6.31 |
| CHEMBL302783 | — | — | 1 | 6.07 |
| CHEMBL5280834 | — | — | 1 | 5.94 |
| CHEMBL5274182 | — | — | 1 | 5.92 |
| CHEMBL5282066 | — | — | 1 | 5.91 |
| CHEMBL1618358 | — | — | 1 | 5.90 |
| CHEMBL1370446 | METIZOLINE | 2.0 | 1 | 5.86 |
| CHEMBL1591 | DEMECLOCYCLINE | 4.0 | 1 | 5.86 |
| CHEMBL157351 | — | — | 1 | 5.79 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 5.77 |
| CHEMBL595227 | — | — | 1 | 5.66 |
| CHEMBL418068 | RHEIN | — | 1 | 5.66 |
| CHEMBL28626 | MORIN | — | 1 | 5.59 |
| CHEMBL4567838 | — | — | 1 | 5.58 |
| CHEMBL212579 | BENZAMIL | — | 1 | 5.55 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | 5.52 |
| CHEMBL239800 | FENOBAM ANHYDROUS | 2.0 | 1 | 5.48 |
| CHEMBL289277 | EMODIN | — | 1 | 5.34 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 5.32 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | — | 1 | 5.30 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572939 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL465179 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5275957 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL302783 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5280834 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5274182 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5282066 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1618358 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL1370446 | METIZOLINE | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL1591 | DEMECLOCYCLINE | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL157351 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL95 | TACRINE | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL595227 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL418068 | RHEIN | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL28626 | MORIN | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL4567838 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL212579 | BENZAMIL | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL239800 | FENOBAM ANHYDROUS | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL289277 | EMODIN | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL945 | AMILORIDE | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 7940.0 | nM | 5.10 |