Compound Detail
CHEMBL212579
BENZAMIL Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL212579 |
| Name | BENZAMIL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KXDROGADUISDGY-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
319.8
MW (Da)
0.54
ALogP
5
HBA
4
HBD
145.3
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Amiloride-sensitive sodium channel subunit alpha CHEMBL1791 | IC50 | 7.18 | 7.18 | 66.0 | 1 |
| Alpha-ketoglutarate-dependent dioxygenase FTO CHEMBL2331065 | IC50 | 5.55 | 5.55 | 2790.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 20.0 | nM | 7.7 | Inhibition of human ENaC in HBE cells by short-circuit current technique | 22197144 |
| Amiloride-sensitive sodium channel subunit alpha | IC50 | = | 66.0 | nM | 7.18 | Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysi... | 16821771 |
| Alpha-ketoglutarate-dependent dioxygenase FTO | IC50 | = | 2790.0 | nM | 5.55 | Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RN... | 34792334 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 16821771 | 10.1021/jm051134w | Epithelial cell | 1 |
| 16821771 | 10.1021/jm051134w | Amiloride-sensitive sodium channel subunit alpha | 1 |
| 22197144 | 10.1016/j.bmcl.2011.12.016 | Unchecked | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 34792334 | 10.1021/acs.jmedchem.1c01694 | Alpha-ketoglutarate-dependent dioxygenase FTO | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine