Assay Detail
Functional
CHEMBL5256650
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Cytotoxicity against human SNU-16 cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.36 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3701238 | FUTIBATINIB | 4.0 | 1 | 8.43 |
| CHEMBL3701241 | — | — | 1 | 8.13 |
| CHEMBL3701243 | — | — | 1 | 8.08 |
| CHEMBL3701255 | — | — | 1 | 7.50 |
| CHEMBL5269016 | — | — | 1 | 7.48 |
| CHEMBL5278505 | — | — | 1 | 7.37 |
| CHEMBL5287545 | — | — | 1 | 6.95 |
| CHEMBL5268467 | — | — | 1 | 6.44 |
| CHEMBL3701282 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3701238 | FUTIBATINIB | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3701241 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3701243 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL3701255 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5269016 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5278505 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5287545 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5268467 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL3701282 | — | IC50 | = | 1420.0 | nM | 5.85 |