Compound Detail
CHEMBL3701282
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Basic Information
| ChEMBL ID | CHEMBL3701282 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DZLNAZQOANZLHT-HNNXBMFYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
420.5
MW (Da)
2.01
ALogP
8
HBA
1
HBD
108.4
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 6.72 | 6.6925 | 190.0 | 4 |
| SNU-16 CHEMBL613529 | IC50 | 5.85 | 5.85 | 1420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 190.0 | nM | 6.72 | Inhibition Assay: When setting conditions for the measurement of the inhibitory ... | - |
| Fibroblast growth factor receptor 2 | IC50 | = | 190.0 | nM | 6.72 | Measurement of Inhibitory Effect on FGFR2 Kinase Activity: When setting conditio... | - |
| Fibroblast growth factor receptor 2 | IC50 | = | 190.0 | nM | 6.72 | Measurement of Inhibitory Effect on FGFR2 Kinase Activity: When setting conditio... | - |
| Fibroblast growth factor receptor 2 | IC50 | = | 244.0 | nM | 6.61 | Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) inc... | 37077386 |
| SNU-16 | IC50 | = | 1420.0 | nM | 5.85 | Cytotoxicity against human SNU-16 cells assessed as inhibition of cell growth me... | 37077386 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Fibroblast growth factor receptor 2 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Epidermal growth factor receptor | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | SNU-16 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | SNU1 | 1 |
Data from ChEMBL 36 via Core Engine