Compound Detail
CHEMBL3701241
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Basic Information
| ChEMBL ID | CHEMBL3701241 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GYXODBZTJVUDOH-UHFFFAOYSA-N |
6
Targets
16
Activities
1
Assay Types
1
PK Parameters
6
Publications
0
Known Names
Molecular Properties
404.4
MW (Da)
1.39
ALogP
8
HBA
1
HBD
108.4
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 16 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 10.0 | 9.68 | 0.1 | 3 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.96 | 8.932 | 1.1 | 5 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.92 | 8.6333 | 1.2 | 3 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.77 | 8.4633 | 1.7 | 3 |
| SNU-16 CHEMBL613529 | IC50 | 8.13 | 8.13 | 7.4 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.52 | 5.52 | 3029.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 28.31 | ng.hr.mL-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37077386 | 10.1021/acsmedchemlett.3c00006 | ADMET | 3 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Fibroblast growth factor receptor 2 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Vascular endothelial growth factor receptor 2 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | SNU-16 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | SNU1 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine