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Assay Detail

CHEMBL5317649

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Functional
Antiproliferative activity against AR-positive human DU-145 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DU-145
Confidence 1 — Organism
Curated By Autocuration

Target

DU-145 (CHEMBL613508)
Type CELL-LINE
Organism Homo sapiens

Publication

Physachenolide C is a Potent, Selective BET Inhibitor.
Zerio CJ, Sivinski J, Wijeratne EMK, Xu YM, Ngo DT, Ambrose AJ, Villa-Celis L, Ghadirian N, Clarkson MW, Zhang DD, Horton NC, Gunatilaka AAL, Fromme R, Chapman E.
J Med Chem (2023) 66 : 913 -933
PubMed 36577036 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 6.60 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 7.40
CHEMBL3605565 1 6.58
CHEMBL4075419 1 5.83
CHEMBL5412959 1 -
CHEMBL5401408 1 -
CHEMBL5416439 1 -
CHEMBL5438438 1 -
CHEMBL1957266 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN EC50 = 40.0 nM 7.40
CHEMBL3605565 EC50 = 263.0 nM 6.58
CHEMBL4075419 EC50 = 1468.1 nM 5.83
CHEMBL5412959 EC50 > 5000.0 nM -
CHEMBL5401408 EC50 > 2000.0 nM -
CHEMBL5416439 EC50 > 2000.0 nM -
CHEMBL5438438 EC50 > 2000.0 nM -
CHEMBL1957266 EC50 > 2000.0 nM -