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Assay Detail

CHEMBL5318491

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen trypomastigotes assessed as reduction in parasite growth incubated for 4 hrs by cell counter analysis
35
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Novel Diarylthioether Compounds as Agents for the Treatment of Chagas Disease.
Beveridge J, Tran E, Deora GS, Huang F, Wang Y, Stockton K, Cotillo I, Martinez Martinez MS, Gonzalez S, Castañeda P, Sherman J, Rodriguez A, Kessler A, Baell JB.
J Med Chem (2023) 66 : 1522 -1542
PubMed 36626662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 5.62 7.70
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5427533 1 7.70
CHEMBL5395058 1 7.50
CHEMBL5434787 1 6.90
CHEMBL5397767 1 6.80
CHEMBL5438911 1 6.70
CHEMBL5413185 1 6.60
CHEMBL5432704 1 6.50
CHEMBL5432001 1 6.50
CHEMBL5406736 1 6.10
CHEMBL5407135 1 6.10
CHEMBL5429749 1 6.00
CHEMBL110 BENZNIDAZOLE 4.0 1 5.90
CHEMBL5420398 1 5.90
CHEMBL5423368 1 5.70
CHEMBL5402441 1 5.60
CHEMBL5419416 1 5.60
CHEMBL5399471 1 5.30
CHEMBL5423856 1 5.20
CHEMBL5430064 1 5.20
CHEMBL5428191 1 5.20
CHEMBL5396106 1 5.20
CHEMBL5407868 1 5.10
CHEMBL5410899 1 4.90
CHEMBL5396196 1 4.80
CHEMBL5428171 1 4.80
CHEMBL5435791 1 4.70
CHEMBL5401534 1 4.70
CHEMBL5405577 1 4.70
CHEMBL5396652 1 4.60
CHEMBL5409114 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5427533 IC50 = 19.95 nM 7.70
CHEMBL5395058 IC50 = 31.62 nM 7.50
CHEMBL5434787 IC50 = 125.89 nM 6.90
CHEMBL5397767 IC50 = 158.49 nM 6.80
CHEMBL5438911 IC50 = 199.53 nM 6.70
CHEMBL5413185 IC50 = 251.19 nM 6.60
CHEMBL5432704 IC50 = 316.23 nM 6.50
CHEMBL5432001 IC50 = 316.23 nM 6.50
CHEMBL5407135 IC50 = 794.33 nM 6.10
CHEMBL5406736 IC50 = 794.33 nM 6.10
CHEMBL5429749 IC50 = 1000.0 nM 6.00
CHEMBL110 BENZNIDAZOLE IC50 = 1258.93 nM 5.90
CHEMBL5420398 IC50 = 1258.93 nM 5.90
CHEMBL5423368 IC50 = 1995.26 nM 5.70
CHEMBL5419416 IC50 = 2511.89 nM 5.60
CHEMBL5402441 IC50 = 2511.89 nM 5.60
CHEMBL5399471 IC50 = 5011.87 nM 5.30
CHEMBL5423856 IC50 = 6309.57 nM 5.20
CHEMBL5396106 IC50 = 6309.57 nM 5.20
CHEMBL5428191 IC50 = 6309.57 nM 5.20
CHEMBL5430064 IC50 = 6309.57 nM 5.20
CHEMBL5407868 IC50 = 7943.28 nM 5.10
CHEMBL5410899 IC50 = 12589.25 nM 4.90
CHEMBL5396196 IC50 = 15848.93 nM 4.80
CHEMBL5428171 IC50 = 15848.93 nM 4.80
CHEMBL5435791 IC50 = 19952.62 nM 4.70
CHEMBL5401534 IC50 = 19952.62 nM 4.70
CHEMBL5405577 IC50 = 19952.62 nM 4.70
CHEMBL5396652 IC50 = 25118.86 nM 4.60
CHEMBL5409114 IC50 = 31622.78 nM 4.50
CHEMBL5408342 IC50 = 31622.78 nM 4.50
CHEMBL5423606 IC50 = 50118.72 nM 4.30
CHEMBL3431410 Activity - -
CHEMBL5435517 IC50 > 50118.72 nM -
CHEMBL5433520 IC50 > 50118.72 nM -