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Assay Detail

CHEMBL5326641

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infected in mouse L929 cells assessed as parasite growth inhibition measured after 7 days by CPRG/Nonidet based assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type L929
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Structural design, synthesis, and anti-Trypanosomatidae profile of new Pyridyl-thiazolidinones.
Conceição JMD, Santos ACDS, Brayner FA, Alves LC, Pinto AF, Brondani GL, Oliveira Filho GB, Bedor DCG, Silva JWVD, Sales Junior PA, Cavalcante MKA, Silva EDD, Pereira VRA, Leite ACL.
Eur J Med Chem (2023) 254 : 115310 -115310
PubMed 37062170 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.58 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL282346 1 7.16
CHEMBL4584496 1 6.72
CHEMBL5403553 1 6.22
CHEMBL5436197 1 6.21
CHEMBL5400848 1 6.19
CHEMBL446813 1 6.12
CHEMBL5420380 1 6.12
CHEMBL5421644 1 6.09
CHEMBL5437816 1 6.08
CHEMBL5438957 1 6.05
CHEMBL416771 1 5.86
CHEMBL25988 1 5.80
CHEMBL5405368 1 5.79
CHEMBL3250581 1 5.54
CHEMBL5414893 1 5.42
CHEMBL1765791 1 5.25
CHEMBL5430151 1 5.24
CHEMBL3335808 1 5.20
CHEMBL110 BENZNIDAZOLE 4.0 1 5.20
CHEMBL5433217 1 5.12
CHEMBL5423362 1 5.09
CHEMBL5412130 1 5.06
CHEMBL5438936 1 5.04
CHEMBL5409601 1 4.16
CHEMBL5404866 1 4.14
CHEMBL5418866 1 4.09
CHEMBL5417504 1 -
CHEMBL3198028 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL282346 IC50 = 70.0 nM 7.16
CHEMBL4584496 IC50 = 190.0 nM 6.72
CHEMBL5403553 IC50 = 600.0 nM 6.22
CHEMBL5436197 IC50 = 620.0 nM 6.21
CHEMBL5400848 IC50 = 640.0 nM 6.19
CHEMBL446813 IC50 = 760.0 nM 6.12
CHEMBL5420380 IC50 = 750.0 nM 6.12
CHEMBL5421644 IC50 = 810.0 nM 6.09
CHEMBL5437816 IC50 = 840.0 nM 6.08
CHEMBL5438957 IC50 = 890.0 nM 6.05
CHEMBL416771 IC50 = 1390.0 nM 5.86
CHEMBL25988 IC50 = 1600.0 nM 5.80
CHEMBL5405368 IC50 = 1610.0 nM 5.79
CHEMBL3250581 IC50 = 2880.0 nM 5.54
CHEMBL5414893 IC50 = 3810.0 nM 5.42
CHEMBL1765791 IC50 = 5660.0 nM 5.25
CHEMBL5430151 IC50 = 5810.0 nM 5.24
CHEMBL3335808 IC50 = 6300.0 nM 5.20
CHEMBL110 BENZNIDAZOLE IC50 = 6300.0 nM 5.20
CHEMBL5433217 IC50 = 7590.0 nM 5.12
CHEMBL5423362 IC50 = 8210.0 nM 5.09
CHEMBL5412130 IC50 = 8740.0 nM 5.06
CHEMBL5438936 IC50 = 9150.0 nM 5.04
CHEMBL5409601 IC50 = 68870.0 nM 4.16
CHEMBL5404866 IC50 = 72360.0 nM 4.14
CHEMBL5418866 IC50 = 80540.0 nM 4.09
CHEMBL5417504 IC50 = 235480.0 nM -
CHEMBL3198028 IC50 = 242190.0 nM -