Assay Detail
Functional
CHEMBL5330150
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Antitrypanosomal activity against of Trypanosoma cruzi epimastigotes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of the 2-arylquinazoline-4(3<i>H</i>)one scaffold for a selective and potent antitrypanosomal agent: modulation of the mechanism of action through chemical functionalization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.10 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434485 | — | — | 1 | 6.20 |
| CHEMBL5397544 | — | — | 1 | 6.11 |
| CHEMBL5408126 | — | — | 1 | 5.39 |
| CHEMBL5407773 | — | — | 1 | 5.04 |
| CHEMBL5431637 | — | — | 1 | 4.94 |
| CHEMBL5436408 | — | — | 1 | 4.84 |
| CHEMBL5416931 | — | — | 1 | 4.75 |
| CHEMBL5428702 | — | — | 1 | 4.75 |
| CHEMBL1163173 | — | — | 1 | 4.74 |
| CHEMBL2058057 | — | — | 1 | 4.70 |
| CHEMBL18688 | — | — | 1 | 4.64 |
| CHEMBL5431468 | — | — | 1 | - |
| CHEMBL5406203 | — | — | 1 | - |
| CHEMBL5422583 | — | — | 1 | - |
| CHEMBL5418693 | — | — | 1 | - |
| CHEMBL3289109 | — | — | 1 | - |
| CHEMBL5402893 | — | — | 1 | - |
| CHEMBL5439802 | — | — | 1 | - |
| CHEMBL127066 | — | — | 1 | - |
| CHEMBL2058056 | — | — | 1 | - |
| CHEMBL4060330 | — | — | 1 | - |
| CHEMBL5427953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434485 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5397544 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5408126 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL5407773 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL5431637 | — | IC50 | = | 11480.0 | nM | 4.94 |
| CHEMBL5436408 | — | IC50 | = | 14320.0 | nM | 4.84 |
| CHEMBL5416931 | — | IC50 | = | 17990.0 | nM | 4.75 |
| CHEMBL5428702 | — | IC50 | = | 17950.0 | nM | 4.75 |
| CHEMBL1163173 | — | IC50 | = | 18050.0 | nM | 4.74 |
| CHEMBL2058057 | — | IC50 | = | 19780.0 | nM | 4.70 |
| CHEMBL18688 | — | IC50 | = | 22670.0 | nM | 4.64 |
| CHEMBL5431468 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5406203 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5422583 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5418693 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3289109 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5402893 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5439802 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL127066 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2058056 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4060330 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5427953 | — | IC50 | > | 25000.0 | nM | - |