Assay Detail
ADMET
CHEMBL5332456
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Inhibition of CYP3A4M (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.38 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL655 | MIDAZOLAM | 4.0 | 1 | 7.10 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 5.66 |
| CHEMBL5440893 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL655 | MIDAZOLAM | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL175691 | RILPIVIRINE | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL5440893 | — | IC50 | > | 50000.0 | nM | - |