Assay Detail
Functional
CHEMBL5365897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human mu opioid receptor stably transfected in CHO cells by cAMP assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.54 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5411716 | — | — | 1 | 9.48 |
| CHEMBL5422389 | — | — | 1 | 9.06 |
| CHEMBL5407881 | — | — | 1 | 8.70 |
| CHEMBL5433189 | — | — | 1 | 8.14 |
| CHEMBL5437684 | — | — | 1 | 8.12 |
| CHEMBL4467777 | — | — | 1 | 7.89 |
| CHEMBL5434293 | — | — | 1 | 7.84 |
| CHEMBL5399232 | — | — | 1 | 7.68 |
| CHEMBL5410817 | — | — | 1 | 7.54 |
| CHEMBL5422499 | — | — | 1 | 7.21 |
| CHEMBL5412978 | — | — | 1 | 6.98 |
| CHEMBL5409642 | — | — | 1 | 6.75 |
| CHEMBL5409840 | — | — | 1 | 6.61 |
| CHEMBL5403495 | — | — | 1 | 6.46 |
| CHEMBL5419159 | — | — | 1 | 6.11 |
| CHEMBL5435875 | — | — | 1 | 6.02 |
| CHEMBL5414957 | — | — | 1 | - |
| CHEMBL5397104 | — | — | 1 | - |
| CHEMBL5429557 | — | — | 1 | - |
| CHEMBL5424587 | — | — | 1 | - |
| CHEMBL5405925 | — | — | 1 | - |
| CHEMBL5421526 | — | — | 1 | - |
| CHEMBL5435711 | — | — | 1 | - |
| CHEMBL5403243 | — | — | 1 | - |
| CHEMBL5407379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5411716 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL5422389 | — | EC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5407881 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5433189 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5437684 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4467777 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5434293 | — | EC50 | = | 14.5 | nM | 7.84 |
| CHEMBL5399232 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5410817 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5422499 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5412978 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5409642 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5409840 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5403495 | — | EC50 | = | 346.0 | nM | 6.46 |
| CHEMBL5419159 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5435875 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5414957 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5397104 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5429557 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5424587 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5405925 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5421526 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5435711 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5403243 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5407379 | — | EC50 | > | 3000.0 | nM | - |