Assay Detail
Functional
CHEMBL5442703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GPCR PRESTO-Tango dose-response in agonist mode with target: ADRB2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Category | GPCR beta-arrestin recruitment assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - GPCR Dose-Respose
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.82 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3039518 | BATEFENTEROL | 2.0 | 1 | 7.97 |
| CHEMBL2105510 | ZINTEROL HYDROCHLORIDE | -1.0 | 1 | 7.45 |
| CHEMBL1374751 | CIMATEROL | 2.0 | 1 | 7.15 |
| CHEMBL1095777 | INDACATEROL | 4.0 | 1 | 7.08 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.21 |
| CHEMBL5087452 | — | — | 1 | 5.03 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3039518 | BATEFENTEROL | EC50 | = | 10.63 | nM | 7.97 |
| CHEMBL2105510 | ZINTEROL HYDROCHLORIDE | EC50 | = | 35.66 | nM | 7.45 |
| CHEMBL1374751 | CIMATEROL | EC50 | = | 70.43 | nM | 7.15 |
| CHEMBL1095777 | INDACATEROL | EC50 | = | 83.28 | nM | 7.08 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 615.46 | nM | 6.21 |
| CHEMBL5087452 | — | EC50 | = | 9380.02 | nM | 5.03 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | EC50 | > | 10000.0 | nM | - |