Assay Detail
Functional
CHEMBL5537733
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Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 9.00 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.20 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.75 |
| CHEMBL3692688 | — | — | 1 | 5.03 |
| CHEMBL3110004 | — | — | 1 | 4.89 |
| CHEMBL5579748 | — | — | 1 | 4.33 |
| CHEMBL5563683 | — | — | 1 | - |
| CHEMBL5571522 | — | — | 1 | - |
| CHEMBL5570082 | — | — | 1 | - |
| CHEMBL5572569 | — | — | 1 | - |
| CHEMBL5571764 | — | — | 1 | - |
| CHEMBL5571685 | — | — | 1 | - |
| CHEMBL3692573 | — | — | 1 | - |
| CHEMBL5572470 | — | — | 1 | - |
| CHEMBL5571546 | — | — | 1 | - |
| CHEMBL5575926 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 6.28 | nM | 8.20 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3692688 | — | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL3110004 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5579748 | — | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL5563683 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5571522 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL5570082 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5572569 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL5571764 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5571685 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL3692573 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5572470 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL5571546 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL5575926 | — | IC50 | ~ | 100000.0 | nM | - |