Assay Detail
Binding
CHEMBL5543914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX-1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.81 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275809 | FR-122047 | — | 1 | 7.55 |
| CHEMBL361504 | — | — | 1 | 7.30 |
| CHEMBL26915 | SC-560 | — | 1 | 7.16 |
| CHEMBL365033 | — | — | 1 | 7.05 |
| CHEMBL363228 | — | — | 1 | 6.30 |
| CHEMBL5574567 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275809 | FR-122047 | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL361504 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL26915 | SC-560 | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL365033 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL363228 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5574567 | — | IC50 | = | 3200.0 | nM | 5.50 |