Assay Detail
Binding
CHEMBL5584773
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Inhibition of c-MET (unknown origin)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in c-Met-based dual inhibitors in the treatment of cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.74 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596808 | — | — | 1 | 9.10 |
| CHEMBL3808948 | — | — | 1 | 9.00 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.62 |
| CHEMBL5597352 | — | — | 1 | 8.55 |
| CHEMBL4758378 | — | — | 1 | 8.27 |
| CHEMBL5596073 | — | — | 1 | 8.19 |
| CHEMBL5518098 | — | — | 1 | 8.10 |
| CHEMBL5598379 | — | — | 1 | 8.08 |
| CHEMBL5597117 | — | — | 1 | 8.00 |
| CHEMBL5596801 | — | — | 1 | 8.00 |
| CHEMBL5269169 | — | — | 1 | 7.90 |
| CHEMBL5095063 | ENVONALKIB | 2.0 | 1 | 7.90 |
| CHEMBL5598343 | — | — | 1 | 7.86 |
| CHEMBL5597495 | — | — | 1 | 7.84 |
| CHEMBL5267265 | — | — | 1 | 7.84 |
| CHEMBL5596908 | — | — | 1 | 7.50 |
| CHEMBL3984441 | NINGETINIB | 2.0 | 1 | 7.48 |
| CHEMBL5596702 | — | — | 1 | 7.47 |
| CHEMBL5596227 | — | — | 1 | 7.40 |
| CHEMBL5598344 | — | — | 1 | 6.83 |
| CHEMBL5596467 | — | — | 1 | 5.18 |
| CHEMBL5596177 | — | — | 1 | 5.10 |
| CHEMBL5598465 | — | — | 1 | - |
| CHEMBL5597950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596808 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3808948 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5597352 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4758378 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5596073 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5518098 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5598379 | — | IC50 | = | 8.32 | nM | 8.08 |
| CHEMBL5597117 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5596801 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5269169 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL5095063 | ENVONALKIB | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5598343 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL5597495 | — | IC50 | = | 14.37 | nM | 7.84 |
| CHEMBL5267265 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL5596908 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3984441 | NINGETINIB | IC50 | = | 33.39 | nM | 7.48 |
| CHEMBL5596702 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL5596227 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5598344 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5596467 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL5596177 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5598465 | — | IC50 | = | 151000.0 | nM | - |
| CHEMBL5597950 | — | IC50 | = | 190000.0 | nM | - |