Compound Detail
CHEMBL3808948
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Basic Information
| ChEMBL ID | CHEMBL3808948 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AREYWCZYVPSHGS-NVMNQCDNSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
438.5
MW (Da)
2.54
ALogP
6
HBA
2
HBD
94.7
PSA (Ų)
0.70
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 8.15 | 7.7 | 7.0 | 2 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.77 | 7.77 | 17.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 1.0 | nM | 9.0 | Inhibition of c-MET (unknown origin) | 38733884 |
| Tyrosine-protein kinase receptor UFO | IC50 | = | 7.0 | nM | 8.15 | Inhibition of human AXL by radiometric assay | 26555154 |
| Fibroblast growth factor receptor 3 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of FGFR3 (unknown origin) | 38733884 |
| Fibroblast growth factor receptor 2 | IC50 | = | 17.0 | nM | 7.77 | Inhibition of FGFR2 (unknown origin) | 38733884 |
| Fibroblast growth factor receptor 1 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of FGFR1 (unknown origin) | 38733884 |
| Tyrosine-protein kinase receptor UFO | IC50 | = | 56.0 | nM | 7.25 | Inhibition of human AXL expressed in MEF cells by ELISA | 26555154 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26555154 | 10.1021/acs.jmedchem.5b01273 | Tyrosine-protein kinase receptor UFO | 2 |
| 38733884 | 10.1016/j.ejmech.2024.116477 | Hepatocyte growth factor receptor | 1 |
| 38733884 | 10.1016/j.ejmech.2024.116477 | Fibroblast growth factor receptor 1 | 1 |
| 38733884 | 10.1016/j.ejmech.2024.116477 | Fibroblast growth factor receptor 2 | 1 |
| 38733884 | 10.1016/j.ejmech.2024.116477 | Fibroblast growth factor receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine