Compound Detail
CHEMBL5518098
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Basic Information
| ChEMBL ID | CHEMBL5518098 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OLFDNCRQUIKEDM-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
529.5
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.1 | 8.1 | 8.0 | 2 |
| MHCC97H CHEMBL4296470 | IC50 | 8.0 | 8.0 | 10.0 | 2 |
| HCCLM3 CHEMBL5465453 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.0 | 7.0 | 99.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 8.0 | nM | 8.1 | Inhibition of c-Met (unknown origin) incubated for 40 mins in presence of ATP by... | 38716896 |
| Hepatocyte growth factor receptor | IC50 | = | 8.0 | nM | 8.1 | Inhibition of c-MET (unknown origin) | 38733884 |
| MHCC97H | IC50 | = | 10.0 | nM | 8.0 | Antiproliferative activity against human MHCC97H cells assessed as reduction in ... | 38716896 |
| MHCC97H | IC50 | = | 10.0 | nM | 8.0 | Cytotoxicity against human MHCC97H cells assessed as cell growth inhibition incu... | 38733884 |
| HCCLM3 | IC50 | = | 13.0 | nM | 7.89 | Cytotoxicity against human HCCLM3 cells assessed as cell growth inhibition incub... | 38733884 |
| Unchecked | IC50 | = | 99.0 | nM | 7.0 | Inhibition of TrxR (unknown origin) expressed in MHCC97H cells incubated for 24 ... | 38716896 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38716896 | 10.1021/acs.jmedchem.3c02426 | MHCC97H | 1 |
| 38716896 | 10.1021/acs.jmedchem.3c02426 | Hepatocyte growth factor receptor | 1 |
| 38716896 | 10.1021/acs.jmedchem.3c02426 | Unchecked | 1 |
| 38733884 | 10.1016/j.ejmech.2024.116477 | Hepatocyte growth factor receptor | 1 |
| 38733884 | 10.1016/j.ejmech.2024.116477 | HCCLM3 | 1 |
| 38733884 | 10.1016/j.ejmech.2024.116477 | MHCC97H | 1 |
Data from ChEMBL 36 via Core Engine