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Assay Detail

CHEMBL5636818

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Functional
Antiviral activity against HCoV-OC43 infected in human NCI-H460 cells treated for 72 hrs by CPE inhibition assay
ChEMBL ↗
86
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human coronavirus OC43
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Autocuration

Target

Human coronavirus OC43 (CHEMBL5209665) ↗
Type ORGANISM
Organism Human coronavirus OC43

Publication

Design, synthesis, and structure-activity relationships of a novel class of quinazoline derivatives as coronavirus inhibitors.
Zhou S, Wang K, Hu Z, Chen T, Dong Y, Gao R, Wu M, Li Y, Ji X.
Eur J Med Chem (2023) 261 : 115831 -115831
PubMed 37813064 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 86 5.75 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5646566 — — 1 7.05
CHEMBL5647387 — — 1 7.00
CHEMBL5646608 — — 1 6.92
CHEMBL4065616 REMDESIVIR 4.0 1 6.85
CHEMBL5646944 — — 1 6.82
CHEMBL5647018 — — 1 6.80
CHEMBL5641523 — — 1 6.64
CHEMBL5639631 — — 1 6.55
CHEMBL5647273 — — 1 6.54
CHEMBL5639127 — — 1 6.51
CHEMBL5639467 — — 1 6.46
CHEMBL5647521 — — 1 6.43
CHEMBL5646596 — — 1 6.33
CHEMBL5646485 — — 1 6.32
CHEMBL5647006 — — 1 6.32
CHEMBL5646536 — — 1 6.32
CHEMBL5646807 — — 1 6.32
CHEMBL5647261 — — 1 6.32
CHEMBL5639335 — — 1 6.28
CHEMBL5639620 — — 1 6.16
CHEMBL5646948 — — 1 6.16
CHEMBL5646476 — — 1 6.16
CHEMBL5641829 — — 1 6.06
CHEMBL5646953 — — 1 5.94
CHEMBL5639848 — — 1 5.92
CHEMBL5639983 — — 1 5.92
CHEMBL5647182 — — 1 5.84
CHEMBL5639352 — — 1 5.84
CHEMBL5646457 — — 1 5.84
CHEMBL5647146 — — 1 5.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5646566 — EC50 = 90.0 nM 7.05
CHEMBL5647387 — EC50 = 100.0 nM 7.00
CHEMBL5646608 — EC50 = 120.0 nM 6.92
CHEMBL4065616 REMDESIVIR EC50 = 140.0 nM 6.85
CHEMBL5646944 — EC50 = 150.0 nM 6.82
CHEMBL5647018 — EC50 = 160.0 nM 6.80
CHEMBL5641523 — EC50 = 230.0 nM 6.64
CHEMBL5639631 — EC50 = 280.0 nM 6.55
CHEMBL5647273 — EC50 = 290.0 nM 6.54
CHEMBL5639127 — EC50 = 310.0 nM 6.51
CHEMBL5639467 — EC50 = 350.0 nM 6.46
CHEMBL5647521 — EC50 = 370.0 nM 6.43
CHEMBL5646596 — EC50 = 470.0 nM 6.33
CHEMBL5647261 — EC50 = 480.0 nM 6.32
CHEMBL5647006 — EC50 = 480.0 nM 6.32
CHEMBL5646536 — EC50 = 480.0 nM 6.32
CHEMBL5646485 — EC50 = 480.0 nM 6.32
CHEMBL5646807 — EC50 = 480.0 nM 6.32
CHEMBL5639335 — EC50 = 530.0 nM 6.28
CHEMBL5639620 — EC50 = 690.0 nM 6.16
CHEMBL5646948 — EC50 = 690.0 nM 6.16
CHEMBL5646476 — EC50 = 690.0 nM 6.16
CHEMBL5641829 — EC50 = 880.0 nM 6.06
CHEMBL5646953 — EC50 = 1140.0 nM 5.94
CHEMBL5639983 — EC50 = 1190.0 nM 5.92
CHEMBL5639848 — EC50 = 1190.0 nM 5.92
CHEMBL5647182 — EC50 = 1430.0 nM 5.84
CHEMBL5639352 — EC50 = 1430.0 nM 5.84
CHEMBL5646457 — EC50 = 1430.0 nM 5.84
CHEMBL5647146 — EC50 = 1430.0 nM 5.84
CHEMBL5639317 — EC50 = 1430.0 nM 5.84
CHEMBL5647568 — EC50 = 1430.0 nM 5.84
CHEMBL5639577 — EC50 = 1710.0 nM 5.77
CHEMBL5639951 — EC50 = 2060.0 nM 5.69
CHEMBL5639961 — EC50 = 2470.0 nM 5.61
CHEMBL5639616 — EC50 = 2650.0 nM 5.58
CHEMBL5639894 — EC50 = 2970.0 nM 5.53
CHEMBL5646868 — EC50 = 3560.0 nM 5.45
CHEMBL5639436 — EC50 = 3560.0 nM 5.45
CHEMBL5647163 — EC50 = 4280.0 nM 5.37
CHEMBL5641611 — EC50 = 4280.0 nM 5.37
CHEMBL5647359 — EC50 = 5140.0 nM 5.29
CHEMBL5647332 — EC50 = 6170.0 nM 5.21
CHEMBL5641577 — EC50 = 6170.0 nM 5.21
CHEMBL5639920 — EC50 = 9980.0 nM 5.00
CHEMBL5641622 — EC50 = 9980.0 nM 5.00
CHEMBL5647511 — EC50 = 9980.0 nM 5.00
CHEMBL3596992 — EC50 = 12830.0 nM 4.89
CHEMBL5639686 — EC50 = 18520.0 nM 4.73
CHEMBL3596977 — EC50 = 22220.0 nM 4.65