Assay Detail
Binding
CHEMBL615400
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Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.
42
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Central serotonin receptors as targets for drug research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 5.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18785 | RU-24969 | — | 1 | 8.70 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.70 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 8.70 |
| CHEMBL19215 | METERGOLINE | 2.0 | 1 | 7.70 |
| CHEMBL274866 | — | — | 1 | 7.70 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.30 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 7.00 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 6.80 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.80 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.64 |
| CHEMBL452861 | LEVOPROPRANOLOL | 2.0 | 1 | 6.52 |
| CHEMBL1434583 | — | — | 1 | 6.04 |
| CHEMBL8642 | — | — | 1 | 5.99 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 5.96 |
| CHEMBL18762 | — | — | 1 | 5.88 |
| CHEMBL134519 | — | — | 2 | 5.64 |
| CHEMBL16247 | — | — | 1 | 5.58 |
| CHEMBL8600 | DOM | — | 1 | 5.54 |
| CHEMBL8569 | — | — | 1 | 5.50 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 5.48 |
| CHEMBL267526 | — | — | 1 | 5.47 |
| CHEMBL18786 | CINANSERIN | 2.0 | 1 | 5.46 |
| CHEMBL16451 | — | — | 1 | 5.46 |
| CHEMBL317634 | — | — | 1 | 5.45 |
| CHEMBL19044 | — | — | 1 | 5.41 |
| CHEMBL69700 | — | — | 2 | 5.38 |
| CHEMBL1788248 | — | — | 1 | 5.37 |
| CHEMBL8224 | — | — | 1 | 5.34 |
| CHEMBL468880 | — | — | 1 | 5.30 |
| CHEMBL405 | AMPHETAMINE | 4.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18785 | RU-24969 | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL39 | SEROTONIN | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL19215 | METERGOLINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL274866 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL500 | PINDOLOL | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL267930 | SPIPERONE | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL452861 | LEVOPROPRANOLOL | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL1434583 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL8642 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL6437 | MIANSERIN | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL18762 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL134519 | — | Ki | = | 2290.0 | nM | 5.64 |
| CHEMBL134519 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL16247 | — | Ki | = | 2660.0 | nM | 5.58 |
| CHEMBL8600 | DOM | Ki | = | 2890.0 | nM | 5.54 |
| CHEMBL8569 | — | Ki | = | 3170.0 | nM | 5.50 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 3340.0 | nM | 5.48 |
| CHEMBL267526 | — | Ki | = | 3370.0 | nM | 5.47 |
| CHEMBL16451 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL18786 | CINANSERIN | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL317634 | — | Ki | = | 3550.0 | nM | 5.45 |
| CHEMBL19044 | — | Ki | = | 3870.0 | nM | 5.41 |
| CHEMBL69700 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL69700 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL1788248 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL8224 | — | Ki | = | 4570.0 | nM | 5.34 |
| CHEMBL468880 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL405 | AMPHETAMINE | Ki | = | 7660.0 | nM | 5.12 |
| CHEMBL1927025 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL1788278 | — | Ki | = | 13200.0 | nM | 4.88 |
| CHEMBL8301 | — | Ki | = | 14100.0 | nM | 4.85 |
| CHEMBL8389 | — | Ki | = | 46400.0 | nM | 4.33 |
| CHEMBL277540 | — | Ki | = | 64600.0 | nM | 4.19 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | Ki | = | 79400.0 | nM | 4.10 |
| CHEMBL18331 | PIRENPERONE | Ki | - | nM | - | |
| CHEMBL12314 | MESULERGINE | Ki | - | nM | - | |
| CHEMBL51 | KETANSERIN | Ki | - | nM | - | |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | - | nM | - |