Assay Detail
Binding
CHEMBL616091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was measured on cloned rat 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.80 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26751 | — | — | 1 | 7.51 |
| CHEMBL417473 | — | — | 1 | 7.21 |
| CHEMBL26471 | — | — | 1 | 6.85 |
| CHEMBL27309 | — | — | 1 | 6.50 |
| CHEMBL285352 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26751 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL417473 | — | Ki | = | 61.5 | nM | 7.21 |
| CHEMBL26471 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL27309 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL285352 | — | Ki | = | 1210.0 | nM | 5.92 |