Compound Detail
CHEMBL26471
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL26471 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZVOANBRCVCBCDV-CQSZACIVSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
261.3
MW (Da)
2.98
ALogP
2
HBA
0
HBD
20.3
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 6.85 | 6.85 | 140.0 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 6.54 | 6.54 | 291.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.5 | 6.5 | 317.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 140.0 | nM | 6.85 | Binding affinity was measured on cloned rat 5-hydroxytryptamine 1A receptor whic... | 10753471 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 291.0 | nM | 6.54 | Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor | 10753471 |
| D(2) dopamine receptor | Ki | = | 317.0 | nM | 6.5 | Displacement of [3H]raclopride from human Dopamine receptor D2A | 10753471 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10753471 | 10.1021/jm9911433 | 5-hydroxytryptamine receptor 7 | 1 |
| 10753471 | 10.1021/jm9911433 | 5-hydroxytryptamine receptor 1A | 1 |
| 10753471 | 10.1021/jm9911433 | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine