Assay Detail
Binding
CHEMBL620754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.63 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281924 | — | — | 1 | 8.96 |
| CHEMBL281923 | — | — | 1 | 8.96 |
| CHEMBL280804 | — | — | 1 | 8.52 |
| CHEMBL417473 | — | — | 1 | 8.37 |
| CHEMBL26751 | — | — | 1 | 7.87 |
| CHEMBL281048 | — | — | 1 | 7.87 |
| CHEMBL27251 | — | — | 1 | 7.75 |
| CHEMBL281554 | — | — | 1 | 7.59 |
| CHEMBL27309 | — | — | 1 | 7.56 |
| CHEMBL285352 | — | — | 1 | 6.99 |
| CHEMBL26471 | — | — | 1 | 6.54 |
| CHEMBL282375 | — | — | 1 | 6.27 |
| CHEMBL27247 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281924 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL281923 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL280804 | — | Ki | = | 3.05 | nM | 8.52 |
| CHEMBL417473 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL26751 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL281048 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL27251 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL281554 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL27309 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL285352 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL26471 | — | Ki | = | 291.0 | nM | 6.54 |
| CHEMBL282375 | — | Ki | = | 538.0 | nM | 6.27 |
| CHEMBL27247 | — | Ki | = | 1320.0 | nM | 5.88 |