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Compound Detail

CHEMBL26751

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CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O

Basic Information

ChEMBL ID CHEMBL26751
Phase Preclinical
Structure Type MOL
InChI Key HIYLSOSERAQOHL-RDTXWAMCSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

263.3
MW (Da)
2.83
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H17NO
MW 263.34
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness 1.28

Activity Summary

Ki 6 meas. best 7.87

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 7
CHEMBL3223
Ki 7.87 7.87 13.5 1
Sodium-dependent serotonin transporter
CHEMBL313
Ki 7.85 7.85 14.0 1
D(2) dopamine receptor
CHEMBL217
Ki 7.62 7.62 23.8 1
D(2) dopamine receptor
CHEMBL339
Ki 7.62 7.62 24.0 1
5-hydroxytryptamine receptor 1A
CHEMBL273
Ki 7.51 7.51 31.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10753471 10.1021/jm9911433 5-hydroxytryptamine receptor 7 1
10753471 10.1021/jm9911433 5-hydroxytryptamine receptor 1A 1
10753471 10.1021/jm9911433 D(2) dopamine receptor 1
17228858 10.1021/jm060959i D(2) dopamine receptor 1
17228858 10.1021/jm060959i 5-hydroxytryptamine receptor 1A 1
17228858 10.1021/jm060959i Sodium-dependent serotonin transporter 1

Data from ChEMBL 36 via Core Engine