Assay Detail
Functional
CHEMBL617952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2A receptor of Rat thoracic aorta
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Thoracic aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pA2 | 16 | - | - |
| Kd | 1 | 7.50 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155006 | — | — | 1 | 7.50 |
| CHEMBL111352 | — | — | 1 | - |
| CHEMBL163012 | — | — | 1 | - |
| CHEMBL263790 | — | — | 1 | - |
| CHEMBL142316 | — | — | 1 | - |
| CHEMBL358895 | — | — | 1 | - |
| CHEMBL160907 | — | — | 1 | - |
| CHEMBL141600 | — | — | 1 | - |
| CHEMBL142668 | — | — | 1 | - |
| CHEMBL357517 | — | — | 1 | - |
| CHEMBL320572 | — | — | 2 | - |
| CHEMBL159771 | — | — | 1 | - |
| CHEMBL321682 | — | — | 1 | - |
| CHEMBL143937 | — | — | 1 | - |
| CHEMBL163605 | — | — | 1 | - |
| CHEMBL162901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155006 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL320572 | — | pA2 | - | — | - | |
| CHEMBL163012 | — | pA2 | - | — | - | |
| CHEMBL263790 | — | pA2 | - | — | - | |
| CHEMBL142316 | — | pA2 | - | — | - | |
| CHEMBL358895 | — | pA2 | - | — | - | |
| CHEMBL160907 | — | pA2 | - | — | - | |
| CHEMBL141600 | — | pA2 | - | — | - | |
| CHEMBL142668 | — | pA2 | - | — | - | |
| CHEMBL111352 | — | pA2 | - | — | - | |
| CHEMBL159771 | — | pA2 | - | — | - | |
| CHEMBL321682 | — | pA2 | - | — | - | |
| CHEMBL143937 | — | pA2 | - | — | - | |
| CHEMBL163605 | — | pA2 | - | — | - | |
| CHEMBL320572 | — | pA2 | - | — | - | |
| CHEMBL162901 | — | pA2 | - | — | - | |
| CHEMBL357517 | — | pA2 | - | — | - |