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Assay Detail

CHEMBL619177

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Affinity against 5-hydroxytryptamine receptors in rat fundus model
ChEMBL ↗
45
Total Activities
44
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Serotonin (5-HT) receptor (CHEMBL2094123) ↗
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Serotonin receptor affinities of psychoactive phenalkylamine analogues.
Glennon RA, Liebowitz SM, Anderson GM.
J Med Chem (1980) 23 : 294 -299
PubMed 7365744 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 44 5.74 7.35
pA2 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6607 BROLAMFETAMINE 2.0 1 7.35
CHEMBL8224 — — 1 7.18
CHEMBL8600 DOM — 1 7.12
CHEMBL287047 — — 1 6.85
CHEMBL8642 — — 1 6.83
CHEMBL8389 — — 1 6.81
CHEMBL103700 — — 1 6.65
CHEMBL103779 — — 1 6.52
CHEMBL103436 — — 1 6.50
CHEMBL6731 TENAMFETAMINE 2.0 1 6.45
CHEMBL34108 — — 1 6.28
CHEMBL420095 — — 1 6.10
CHEMBL16247 — — 1 5.93
CHEMBL316698 — — 1 5.89
CHEMBL99959 — — 1 5.65
CHEMBL26687 MESCALINE 1.0 1 5.65
CHEMBL30336 — — 1 5.60
CHEMBL282734 — — 1 5.60
CHEMBL2367824 — — 1 5.56
CHEMBL1124 DEALKYLATED DIETHYLPROPION — 1 5.55
CHEMBL16451 — — 1 5.54
CHEMBL280855 — — 1 5.54
CHEMBL100635 — — 1 5.52
CHEMBL2104047 CATHINONE 2.0 1 5.52
CHEMBL103299 — — 1 5.51
CHEMBL277540 — — 1 5.45
CHEMBL2079629 — — 2 5.38
CHEMBL103331 — — 1 5.38
CHEMBL26019 — — 1 5.36
CHEMBL612 DEXTROAMPHETAMINE 4.0 1 5.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6607 BROLAMFETAMINE Kd = 44.67 nM 7.35
CHEMBL8224 — Kd = 66.07 nM 7.18
CHEMBL8600 DOM Kd = 75.86 nM 7.12
CHEMBL287047 — Kd = 141.25 nM 6.85
CHEMBL8642 — Kd = 147.91 nM 6.83
CHEMBL8389 — Kd = 154.88 nM 6.81
CHEMBL103700 — Kd = 223.87 nM 6.65
CHEMBL103779 — Kd = 302.0 nM 6.52
CHEMBL103436 — Kd = 316.23 nM 6.50
CHEMBL6731 TENAMFETAMINE Kd = 354.81 nM 6.45
CHEMBL34108 — Kd = 524.81 nM 6.28
CHEMBL420095 — Kd = 794.33 nM 6.10
CHEMBL16247 — Kd = 1174.9 nM 5.93
CHEMBL316698 — Kd = 1288.25 nM 5.89
CHEMBL26687 MESCALINE Kd = 2238.72 nM 5.65
CHEMBL99959 — Kd = 2238.72 nM 5.65
CHEMBL30336 — Kd = 2511.89 nM 5.60
CHEMBL282734 — Kd = 2511.89 nM 5.60
CHEMBL2367824 — Kd = 2754.23 nM 5.56
CHEMBL1124 DEALKYLATED DIETHYLPROPION Kd = 2818.38 nM 5.55
CHEMBL16451 — Kd = 2884.03 nM 5.54
CHEMBL280855 — Kd = 2884.03 nM 5.54
CHEMBL100635 — Kd = 3019.95 nM 5.52
CHEMBL2104047 CATHINONE Kd = 3019.95 nM 5.52
CHEMBL103299 — Kd = 3090.3 nM 5.51
CHEMBL277540 — Kd = 3548.13 nM 5.45
CHEMBL2079629 — Kd = 4168.69 nM 5.38
CHEMBL103331 — Kd = 4168.69 nM 5.38
CHEMBL26019 — Kd = 4365.16 nM 5.36
CHEMBL612 DEXTROAMPHETAMINE Kd = 4466.84 nM 5.35
CHEMBL100006 — Kd = 4677.35 nM 5.33
CHEMBL100531 — Kd = 5248.07 nM 5.28
CHEMBL16883 — Kd = 5370.32 nM 5.27
CHEMBL405 AMPHETAMINE Kd = 5370.32 nM 5.27
CHEMBL610 PHENETHYLAMINE Kd = 5495.41 nM 5.26
CHEMBL19393 LEVAMFETAMINE Kd = 6918.31 nM 5.16
CHEMBL2079629 — Kd = 6918.31 nM 5.16
CHEMBL278663 PARA-METHOXYAMPHETAMINE Kd = 7079.46 nM 5.15
CHEMBL101036 — Kd = 7943.28 nM 5.10
CHEMBL30577 — Kd = 8128.31 nM 5.09
CHEMBL30777 — Kd = 8511.38 nM 5.07
CHEMBL11608 TYRAMINE Kd = 8511.38 nM 5.07
CHEMBL318060 — Kd = 11220.18 nM 4.95
CHEMBL276864 — Kd = 11748.98 nM 4.93
CHEMBL136560 (1R,2S)-PHENYLPROPANOLAMINE pA2 - — -