Assay Detail
Functional
CHEMBL619469
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Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.72 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 9.26 |
| CHEMBL104900 | — | — | 1 | 7.82 |
| CHEMBL125371 | — | — | 1 | 7.62 |
| CHEMBL327096 | — | — | 1 | 7.38 |
| CHEMBL104004 | — | — | 1 | 7.29 |
| CHEMBL105362 | — | — | 1 | 7.24 |
| CHEMBL540070 | — | — | 1 | 7.00 |
| CHEMBL123024 | — | — | 1 | 6.96 |
| CHEMBL126010 | — | — | 1 | 6.39 |
| CHEMBL55400 | PROFLAVINE | 2.0 | 1 | 6.33 |
| CHEMBL125180 | — | — | 1 | 6.12 |
| CHEMBL124605 | — | — | 1 | 5.82 |
| CHEMBL340343 | — | — | 1 | 5.82 |
| CHEMBL121823 | — | — | 1 | 5.32 |
| CHEMBL122057 | — | — | 1 | 4.43 |
| CHEMBL436589 | ACRIDONE | — | 1 | - |
| CHEMBL39677 | ACRIDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL104900 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL125371 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL327096 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL104004 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL105362 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL540070 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL123024 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL126010 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL55400 | PROFLAVINE | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL125180 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL124605 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL340343 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL121823 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL122057 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL436589 | ACRIDONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL39677 | ACRIDINE | IC50 | > | 100000.0 | nM | - |