Assay Detail
Functional
CHEMBL621784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth in human ovarian carcinoma cell line (A2780) using the 96 hour continuous exposure sulforhodamine B (SRB) growth delay assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.74 | 10.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | 2.0 | 1 | 10.65 |
| CHEMBL279754 | DSB-120 | — | 1 | 8.14 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.58 |
| CHEMBL164587 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | IC50 | = | 0.0225 | nM | 10.65 |
| CHEMBL279754 | DSB-120 | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL164587 | — | IC50 | = | 2500.0 | nM | 5.60 |