Assay Detail
Functional
CHEMBL624510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against. ovarian carcinoma cell line A2780cisR (cisplatin resistant counter part of A2780).
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.09 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128234 | — | — | 1 | 6.70 |
| CHEMBL279754 | DSB-120 | — | 1 | 6.68 |
| CHEMBL128345 | — | — | 1 | 5.78 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128234 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL279754 | DSB-120 | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL128345 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 6100.0 | nM | 5.21 |