Assay Detail
Functional
CHEMBL643687
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Antagonist activity for Alpha-2 adrenergic receptor against clonidine in rat vas deferences
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on alpha 1-adrenoreceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 5.96 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27013 | — | — | 1 | 6.84 |
| CHEMBL348491 | — | — | 1 | 6.68 |
| CHEMBL150193 | — | — | 1 | 6.55 |
| CHEMBL359103 | — | — | 1 | 6.50 |
| CHEMBL150726 | — | — | 1 | 6.45 |
| CHEMBL149399 | — | — | 1 | 6.31 |
| CHEMBL153056 | — | — | 1 | 5.95 |
| CHEMBL155341 | — | — | 1 | 5.76 |
| CHEMBL154980 | — | — | 1 | 5.73 |
| CHEMBL153576 | — | — | 1 | 5.52 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.43 |
| CHEMBL355968 | — | — | 1 | 5.04 |
| CHEMBL153390 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27013 | — | Kd | = | 144.54 | nM | 6.84 |
| CHEMBL348491 | — | Kd | = | 208.93 | nM | 6.68 |
| CHEMBL150193 | — | Kd | = | 281.84 | nM | 6.55 |
| CHEMBL359103 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL150726 | — | Kd | = | 354.81 | nM | 6.45 |
| CHEMBL149399 | — | Kd | = | 489.78 | nM | 6.31 |
| CHEMBL153056 | — | Kd | = | 1122.02 | nM | 5.95 |
| CHEMBL155341 | — | Kd | = | 1737.8 | nM | 5.76 |
| CHEMBL154980 | — | Kd | = | 1862.09 | nM | 5.73 |
| CHEMBL153576 | — | Kd | = | 3019.95 | nM | 5.52 |
| CHEMBL2 | PRAZOSIN | Kd | = | 3715.35 | nM | 5.43 |
| CHEMBL355968 | — | Kd | = | 9120.11 | nM | 5.04 |
| CHEMBL153390 | — | Kd | = | 16595.87 | nM | 4.78 |