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Compound Detail

CHEMBL153056

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COc1cc2nc(N(C)CCCCCCNC(=O)c3ccco3)nc(N)c2cc1OC

Basic Information

ChEMBL ID CHEMBL153056
Phase Preclinical
Structure Type MOL
InChI Key DWWWSHCYTJWMJU-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

427.5
MW (Da)
3.25
ALogP
8
HBA
2
HBD
115.7
PSA (Ų)
0.45
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H29N5O4
MW 427.51
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.04

Activity Summary

Kd 2 meas. best 8.53

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 8.53 8.53 3.0 1
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 5.95 5.95 1122.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2562855 10.1021/jm00121a011 Adrenergic receptor alpha-1 1
2562855 10.1021/jm00121a011 Adrenergic receptor alpha-2 1
2562855 10.1021/jm00121a011 Adrenergic receptor alpha 1

Data from ChEMBL 36 via Core Engine