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Compound Detail

CHEMBL149399

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COc1cc2nc(N(C)CCCCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC

Basic Information

ChEMBL ID CHEMBL149399
Phase Preclinical
Structure Type MOL
InChI Key HWFZBVSMEVGCOF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

469.6
MW (Da)
4.37
ALogP
8
HBA
1
HBD
107.0
PSA (Ų)
0.37
QED
0
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H35N5O4
MW 469.59
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.91

Activity Summary

Kd 2 meas. best 8.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 8.1 8.1 7.9 1
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 6.31 6.31 489.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2562855 10.1021/jm00121a011 Adrenergic receptor alpha-1 1
2562855 10.1021/jm00121a011 Adrenergic receptor alpha-2 1
2562855 10.1021/jm00121a011 Adrenergic receptor alpha 1

Data from ChEMBL 36 via Core Engine