Assay Detail
Binding
CHEMBL644077
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Binding affinity against adrenergic beta 2 receptor versus 1 nM [3H]dihydroalprenolol in rat cerebral cerebellar membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.55 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126347 | — | — | 1 | 6.15 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.14 |
| CHEMBL287587 | — | — | 1 | 5.82 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 5.38 |
| CHEMBL129190 | — | — | 1 | 5.26 |
| CHEMBL281232 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126347 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL287587 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL129190 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL281232 | — | Ki | = | 29000.0 | nM | 4.54 |