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Compound Detail

CHEMBL129190

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NCC(O)c1cc(O)c(O)c(F)c1

Basic Information

ChEMBL ID CHEMBL129190
Phase Preclinical
Structure Type MOL
InChI Key CMXBGHSRBYAOPP-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

187.2
MW (Da)
0.23
ALogP
4
HBA
4
HBD
86.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H10FNO3
MW 187.17
Aromatic Rings 1
Heavy Atoms 13
NP-Likeness 0.77

Activity Summary

Ki 4 meas. best 6.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 6.82 6.82 150.0 1
Beta-1 adrenergic receptor
CHEMBL3252
Ki 5.82 5.82 1500.0 1
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 5.64 5.64 2300.0 1
Beta-2 adrenergic receptor
CHEMBL3754
Ki 5.26 5.26 5500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8254623 10.1021/jm00076a024 Adrenergic receptor alpha-1 1
8254623 10.1021/jm00076a024 Adrenergic receptor alpha-2 1
8254623 10.1021/jm00076a024 Beta-1 adrenergic receptor 1
8254623 10.1021/jm00076a024 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine