Assay Detail
Binding
CHEMBL644386
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Inhibitory activity against Acetylcholinesterase in electric eel
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.34 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 2 | 7.55 |
| CHEMBL305670 | — | — | 1 | 7.24 |
| CHEMBL307721 | — | — | 1 | 7.16 |
| CHEMBL74107 | — | — | 1 | 6.96 |
| CHEMBL74926 | PHENSERINE | — | 1 | 6.46 |
| CHEMBL308043 | — | — | 1 | 6.01 |
| CHEMBL75729 | — | — | 1 | 6.00 |
| CHEMBL74257 | — | — | 1 | 6.00 |
| CHEMBL74950 | — | — | 1 | 5.77 |
| CHEMBL308503 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL305670 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL307721 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL74107 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL308043 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL75729 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL74257 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL74950 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL308503 | — | IC50 | > | 10000.0 | nM | - |